The physiological states of the skin are characterized by a certain homeostasis linked to the balance of the metabolic pathways. When these pathways are deregulated, the proteic, lipidic and metabolic is affected. It is thus possible to follow a change in the state of the skin by looking at change in the associated molecular profile. The PRISM laboratory (INSERM U1192) in Lille has developed an innovative system laser called SpiderMass composed of 4 parts: 1. A laser used for the micro-sampling of material in vivo, 2. A transport transfer line of the ablated particles, 3. A mass spectrometer that analyzes them in real time and generates the molecular profiles of the epidermis, 4. A data analysis procedure. The SpiderMass(TM) is of great interest for the study of the skin because it allows non-invasive vivo characterization, and therefore without biopsy or sample preparation. In addition, it will complement techniques already used in the research center such as FTIR spectroscopy. Indeed, in acne studies the FTIR allows to obtain only the Fatty Acid Triglycerid ratio while the SpiderMass permits to detail these lipid classes by each observed molecule on the surface of the skin and follow their evolution.
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Signals and molecular profiles (including lipid) of the epidermis
Timeframe: baseline
Molecular profiles (including lipid) of the epidermis according to sampling method and the measurements of the signals obtained method
Timeframe: baseline
Cutaneous hydratation for atopic dermatitis subgroup and its associated control
Timeframe: baseline
State of the cutaneous barrier for atopic dermatitis and corresponding control volunteers
Timeframe: baseline
Global lipid quantity measured on face acnea, scalp seborrheic dermatitis, face rosacea (papulotelangiectasic stage of erythrocouperosis) and corresponding control volunteers
Timeframe: baseline
Skin state evaluation on the lesional and perilesional areas
Timeframe: baseline
Impact of several factors (dermatosis, area, gender, age) on the molecular profiles of the epidermis
Timeframe: baseline