Non-invasive Ventilation and High-speed Oxygen Therapy Effects on Heart Function - HiFlow-Heart S… (NCT04471129) | Clinical Trial Compass
RecruitingNot Applicable
Non-invasive Ventilation and High-speed Oxygen Therapy Effects on Heart Function - HiFlow-Heart Study
France30 participantsStarted 2020-09-16
Plain-language summary
The investigators hypothesize that the airway pressures generated by High Flow Oxygen Therapy could have a beneficial impact in patients with heart failure, particularly by lowering capillary pulmonary arterial pressures. However, results compared to Non-Invasive Ventilation are difficult to predict due to the lack of data in the literature.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Major patient
✓. Patient who has undergone cardiac surgery with extracorporeal circulation for more than 24 hours and has been extubated for at least 6 hours.
✓. Pre-operative heart failure with left ventricular ejection fraction \< 40%.
✓. Invasive monitoring by pulmonary arterial catheter (Swan-Ganz) with transpulmonary thermodilution and by radial arterial catheter intended for use in the intra- and post-operative monitoring of the patient.
✓. Treatment with conventional oxygen therapy (O2C) without an increase in O2 flow for more than 30 minuts, without signs of hypoxemia (SpO292%)
✓. Stable hemodynamic parameters: no changes in hemodynamic parameters (arterial pressures and pulmonary and cardiac index) by more than 10% over the 30 minutes prior to inclusion and no increase in cardiotropic medication for at least 30 minutes.
✓. Patient with an oxygenation rate ≤ 6L
✓. For women of child-bearing age: negative pregnancy test at inclusion
Exclusion criteria
✕. Contraindication to the use of NIV or HFO
✕. Patient with orotracheal intubation or tracheotomy
✕. Renal failure with hemodialysis or hemofiltration
✕. Uncontrolled state of shock (PAS\<90 mmHg and/or cardiac index\<1.8 L/min/m² and/or norepinephrine\>0.2 μg/kg/min and/or dobutamine\>10 μg/kg/min)
What they're measuring
1
High-Flow Oxygen Therapy and Non Invasive Ventilation on left ventricular filling pressures