CompletedPhase 4

Effect of Ciprofloxacin Versus Levofloxacin on QTc-interval and Dysglycemia

Egypt200 participantsStarted 2018-06-01

Plain-language summary

To compare intravenous levofloxacin and ciprofloxacin regarding their risk on the corrected QT interval (QTc) prolongation and dysglycemia in diabetic and non-diabetic patients.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * adult patient (male, female) * age from 18 to 70 years . * Be able to give an informed consent form after understanding for reasonable explanation of clinical trial's purpose, contents and characteristics of clinical drugs * Wiling to participate whole clinical trial periods Exclusion Criteria: * Younger than 18 years or older than 70 years. * Has prolonged QTc before receiving therapy. * With a history of heart diseases. * Received class IA or III antiarrhythmic agents. * Received macrolide antibiotics. * With a history of quinolone allergy. * Pregnant and lactating women.

What they're measuring

Effect of ciprofloxacin versus levofloxacin on QTc interval

Timeframe: before starting antibiotic, after 24 hours, 72 hours from the first dose and after 72 hours from antibiotic cessation

Effect of ciprofloxacin versus levofloxacin on fasting blood glucose

Timeframe: before starting antibiotic, after 24 hours, 72 hours from the first dose and after 72 hours from antibiotic cessation

Trial details

NCT IDNCT04456712

SponsorBeni-Suef University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-11-30

View on ClinicalTrials.gov More QTc Prolongation, Hyperglycemia, Hypoglycemia trials