This study will assess the efficacy of the modified Attachment and Biobehavioral Catch-Up (mABC) Intervention, adapted for use with peripartum mothers receiving medication-assisted treatment for opioid use disorder. The investigators expect that mothers who receive the modified Attachment and Biobehavioral Catch-up Intervention will show more nurturing and sensitive parenting and more adaptive physiological regulation than parents who receive a control intervention. The investigators expect that infants whose mothers receive the modified Attachment and Biobehavioral Catch-up will show better outcomes in attachment, behavior, and physiological regulation than infants of parents who receive the control intervention.
Age range
18 Years – 70 Years
Sex
FEMALE
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Maternal sensitivity
Timeframe: Pre-intervention (3rd trimester)
Maternal sensitivity
Timeframe: Infant age of 3 months
Maternal sensitivity
Timeframe: Infant age of 6 months
Maternal sensitivity
Timeframe: Infant age of 12 months
Maternal methylation of μ-opioid receptor (OPRM1) gene
Timeframe: Pre-intervention (3rd trimester)
Maternal methylation of μ-opioid receptor (OPRM1) gene
Timeframe: Infant age of 12 months
Maternal methylation of oxytocin receptor (OXTR) gene
Timeframe: Pre-intervention (3rd trimester)
Maternal methylation of oxytocin receptor (OXTR) gene
Timeframe: Infant age of 12 months
Infant methylation of μ-opioid receptor (OPRM1) gene
Timeframe: Pre-intervention (3rd trimester)
Infant methylation of μ-opioid receptor (OPRM1) gene
Timeframe: Infant age of 12 months
Maternal neural activity (Event related potentials - ERP) - Own child-other child task
Timeframe: Pre-intervention (3rd trimester)
Maternal neural activity (Event related potentials - ERP) - Own child-other child task
Timeframe: Infant age of 12 months
Maternal neural activity (Event related potentials - ERP) - Reward sensitivity task
Timeframe: Pre-intervention (3rd trimester)
Maternal neural activity (Event related potentials - ERP) - Reward sensitivity task
Timeframe: Infant age of 12 months
Maternal neural activity (Event related potentials - ERP) - Child emotion task
Timeframe: Pre-intervention (3rd trimester)
Maternal neural activity (Event related potentials - ERP) - Child emotion task
Timeframe: Infant age of 12 months
Maternal parasympathetic nervous system activity during Still Face
Timeframe: Pre-intervention (3rd trimester)
Maternal parasympathetic nervous system activity
Timeframe: Infant age of 12 months
Infant parasympathetic nervous system activity
Timeframe: Infant age of 6 months
Infant parasympathetic nervous system activity
Timeframe: Infant age of 12 months
Infant diurnal cortisol production
Timeframe: Infant age of 6 months
Infant diurnal cortisol production
Timeframe: Infant age of 12 months
Infant behavioral regulation
Timeframe: Infant age of 6 months
Infant behavioral regulation
Timeframe: Infant age of 12 months
Infant attachment
Timeframe: Infant age of 12 months
Infant cognitive development
Timeframe: Infant age of 12 months