Opioid Analgesic Reduction Study

Inclusion Criteria: An individual must meet all of the following criteria to be eligible to participate in the study: * Be able to understand the informed consent. * Provide signed and dated informed consent form * Be able to understand all directions for data gathering instruments in English * Be willing and able to comply with all study procedures and be available for the duration of the study * Planning to undergo extraction of one or more partial or fully impacted mandibular 3rd molars * Be 18 years or older * Be in good general health as evidenced by medical history * Women must agree to use one of the following methods of contraception while participating in this study: * contraceptive pill * intra-uterine device * condoms * abstinence Exclusion Criteria: Participants who self-report the following history will be excluded from participating: * History of gastrointestinal bleeding and/or peptic ulcer * History of renal disease (excluding kidney stones) * History of hepatic disease * History of bleeding disorder * History of respiratory depression * Any prior respiratory effect of an opioid or other anesthetic drugs that required respiratory support postoperatively * Active or untreated asthma * History of known allegoric reaction to ibuprofen, acetaminophen, hydrocodone, and/or anesthesia * Currently taking any of the following medications: * CYP3A4 inhibitor, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole…