Active — Not RecruitingNot Applicable

CET- REM (Correlating ECT Response to EEG Markers)

United States31 participantsStarted 2020-10-09

Plain-language summary

Single-center study to determine the relationship between changes in depression symptoms and electroencephalographic (EEG) patterns induced by electroconvulsive therapy (ECT)

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 years or greater * Referral for ECT index course for treatment-resistant depression (unipolar major depressive disorder or bipolar depression), major depressive disorder with psychotic symptoms, schizophrenia or schizoaffective being treated for a depressed episode, unspecified depression Exclusion Criteria: * Schizophrenia or schizoaffective disorder not being treated for a depressed episode.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Interval change in Quick Inventory of Depressive Symptomatology-16 Item Self Report (QIDS-SR16) between ECT sessions.

Timeframe: Up to 8 weeks during patients ECT treatment course

Duration of Central Positive Complexes during ECT treatments.

Timeframe: Up to 8 weeks during patients ECT treatment course

Duration of PGES during ECT treatments.

Timeframe: Up to 8 weeks during patients ECT treatment course

Density of EEG sleep spindles during non-rapid eye movement (NREM) stages N2 on evenings following ECT treatments.

Timeframe: Up to 8 weeks during patients ECT treatment course

Slow wave activity (SWA) during N3 sleep on evenings following ECT treatments

Timeframe: Up to 8 weeks during patients ECT treatment course

Trial details

NCT IDNCT04451135

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06

View on ClinicalTrials.gov More ECT trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Interval change in Quick Inventory of Depressive Symptomatology-16 Item Self Report (QIDS-SR16) between ECT sessions.

Timeframe: Up to 8 weeks during patients ECT treatment course

Duration of Central Positive Complexes during ECT treatments.

Timeframe: Up to 8 weeks during patients ECT treatment course

Duration of PGES during ECT treatments.

Timeframe: Up to 8 weeks during patients ECT treatment course

Density of EEG sleep spindles during non-rapid eye movement (NREM) stages N2 on evenings following ECT treatments.

Timeframe: Up to 8 weeks during patients ECT treatment course

Slow wave activity (SWA) during N3 sleep on evenings following ECT treatments

Timeframe: Up to 8 weeks during patients ECT treatment course