CompletedNot Applicable

Influence of Stress and Psychiatric Symptoms on Children With Tourette Syndrome

United States66 participantsStarted 2021-03-29

Plain-language summary

Investigators propose a cross-sectional, observational pilot study to examine the contribution of stress, family dynamics, and peer relationships to quality of life (QOL) in adolescents with Tourette syndrome (TS). Investigators will recruit two groups of participants: 1) adolescents aged 13-17 years of age with TS and 2) adolescents aged 13-17 without any neurologic or psychiatric diagnoses. Participants and one of their parents/caregivers will complete a series of questionnaires screening for and quantifying the extent of stress and mental health symptoms, including anxiety, depression, obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD). Participants will also complete instruments characterizing family interactions and peer relationships. Adolescents with TS will also undergo a semi-structured interview assessing the severity of their tics.

Who can participate

Age range13 Years – 17 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for adolescents with TS: * adolescent age 13-17 years of age * adolescent diagnosis of Tourette syndrome (TS) * English-speaking adolescent and caregiver (as validated questionnaires are in English) * adolescent and caregiver willingness and ability to complete relevant questionnaires Exclusion Criteria for adolescents with TS: * cognitive or attentional impairment precluding ability of adolescent or caregiver to complete self-report questionnaires * adolescent diagnosis of genetic conditions besides TS and its known comorbidities * adolescent with severe medical conditions unrelated to TS (e.g. uncontrolled seizures, prominent heart conditions) Inclusion Criteria for adolescents without any neurologic or psychiatric diagnoses: * adolescent age 13-17 years of age * no history of tics * English-speaking adolescent and caregiver * adolescent and caregiver willingness and ability to complete relevant questionnaires Exclusion Criteria for adolescents without any neurologic or psychiatric diagnoses: * cognitive or attentional impairment precluding ability of adolescent or caregiver to complete self-report questionnaires * adolescent with severe medical conditions

What they're measuring

Youth Quality of Life Research Version (YQOL-R)

Timeframe: Baseline

Trial details

NCT IDNCT04449003

SponsorVanderbilt University Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-12-28