Effect of Dupilumab on Aspirin Intolerance

Inclusion Criteria: Dupilumab treatment group: * Signed and dated informed consent has been obtained * Age 18 - 70 years * Male or female * Diagnosed with AERD (nasal polyps, allergic asthma, aspirin intolerance) * Chronic rhinosinusitis with nasal polyps (CRSwNP) (according to the European Position Paper on Rhinosinusitis and Nasal Polyps Guidelines)8 * Documented aspirin intolerance * Asthma bronchial diagnosed by a respiratory physician (based on Global -Initiative for Asthma guidelines)9 Exclusion Criteria: * Pregnancy * Clinically significant abnormal laboratory values and active infection (Tbc, HIV, hepatitis A/B/C) * History of malignancy or immunodeficiency * Chronic obstructive lung disorders (COPD), other obstructive lung disorders (bronchiolitis) * Need for systemic corticosteroid therapy 1 month prior to screening visit Eosinophilic pneumonia and Churg-Strauss Syndrome