Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT). These patients frequently suffer from severe widespread pain with very difficult management and control. Chronic neuroinflamation, opioid-induced hyperalgesia, and central sensitization phenomena may explain this complex painful condition. A retrospective, observational, consecutive case series study is designed to determine if opioid-free anesthetic management shows a reduction in postoperative pain and opioid rescues needs in comparison with opioid-based anesthesia management for patients with EDS-HT undergoing crano-cervical fixation.
Age range
18 Years – 60 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Age
Timeframe: Baseline
Sex
Timeframe: Baseline
PO Analgesia
Timeframe: Baseline
Preoperative EVA
Timeframe: Baseline
Preoperative Opioids
Timeframe: Baseline
Postoperative EVA 1
Timeframe: 1 day after surgery
Postoperative EVA 2
Timeframe: 2 days after surgery
Postoperative EVA 4
Timeframe: 4 days after surgery
Postoperative EVA 6
Timeframe: 6 days after surgery
Sufentanil doses 1
Timeframe: From surgery release till first day of hospitalization
Sufentanil doses 2
Timeframe: From first day of hospitalization till second day of hospitalization
Sufentanil doses 4
Timeframe: From second day of hospitalization till fourth day of hospitalization
Sufentanil doses 6
Timeframe: From fourth day of hospitalization till sixth day of hospitalization
Rescue Methadone
Timeframe: Baseline
Morphine dosage 1
Timeframe: From surgery release till first day of hospitalization
Morphine dosage 2
Timeframe: From first day of hospitalization till second day of hospitalization
Morphine dosage 4
Timeframe: From second day of hospitalization till fourth day of hospitalization
Morphine dosage 6
Timeframe: From fourth day of hospitalization till sixth day of hospitalization
Nausea and vomiting
Timeframe: Baseline
Intestinal ileus
Timeframe: Baseline
Constipation
Timeframe: Baseline
Anxiolytic rescue agent
Timeframe: Baseline
Oral ketamine
Timeframe: Baseline
Chronic opioid and hospital discharge
Timeframe: Up to 6 days