CompletedNot Applicable

Clinical and Physiological Assessment of a Nearly Ultra-protective Lung Ventilation Strategy: A Quasi-experimental Preliminary Study in ARDS Patients

Chile10 participantsStarted 2019-09-04

Plain-language summary

This study aims to determine whether a protective mechanical ventilator strategy generates a reduction in the Bohr´s dead space in patients with moderate or severe acute respiratory distress syndrome (ARDS). Commonly used ventilatory strategies in the clinical practice were applied sequentially to assess their impact. Data obtained from volumetric capnography will be recorded after each ventilatory strategy is applied

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age older than 18 years * The requirement of invasive mechanical ventilation for more than 4 hours and less than 72 hours * Severe hypoxemia (PAFI \< 200) secondary to ARDS Exclusion Criteria: * Heart failure stage IV * Chronic obstructive pulmonary disease (COPD) on home oxygen * Bronchopulmonary fistula * Hypovolemic Shock with active hemorrhage * Gastrointestinal bleeding * Oesophageal Varices * Nasopharynx surgery, recent oesophageal or gastric surgery * Massive Pulmonary Thromboembolism * Catastrophic respiratory failure requiring urgent extracorporeal life support * Respiratory acidosis. Hydrogen potential (pH) is less than 7.20 and PaCO2 higher than 60 mmHg at baseline.

What they're measuring

To analyse the effects of different protective mechanical ventilator strategies on Bohr's dead space (VDBohr/VT) in patients with acute respiratory distress syndrome

Timeframe: 150 minutes

Trial details

NCT IDNCT04435613

SponsorClinica las Condes, Chile

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-08-29

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