COLchicine to Prevent Sympathetic Denervation After an Acute Myocardial Infarction

Inclusion Criteria: * Age from 18 to 80 year old * Hospitalization within 12 hours of onset of acute chest pain * Patient must have suffered a documented acute myocardial infarction * Coronary occlusion on initial angiography (culprit artery with aTIMI (Thrombolysis in Myocardial Infarction) flow 1 or 0) * Patient eligible for a revascularization procedure by PTCA (Percutaneous transluminal coronary angioplasty) Exclusion Criteria: * Patients with a history of myocardial infarction prior to the current episode * Patient in cardiogenic shock or with hemodynamic instability * Patients with severe hepatic or renal dysfunction (GFR ≤30 mL/min) * Pregnant women or women of childbearing age without contraception * Treatment with a potent CYP3A4 inhibitor or a P-glycoprotein inhibitor in patients with renal or hepatic impairement * Association with macrolides (except spiramycin) * Association with pristinamycin