TerminatedPhase 4

Desmopressin for Bedwetting in Children With SCD

Stopped: Study was not able to meet recruitment after 9 years of trying to enroll patients on different versions of the protocol and changing recruitment strategies.

United States8 participantsStarted 2020-07-07

Plain-language summary

This study assesses if using the medication desmopressin will decrease nightime bedwetting in children with sickle cell disease.

Who can participate

Age range8 Years – 21 Years

SexALL

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Inclusion criteria

✓. Patients with Hemoglobin SS, SC, SB0thal or SB+thal
✓. Patients with at least two episodes of primary nocturnal enuresis per week or four episodes over the two weeks prior to enrollment.
✓. Patients with secondary enuresis who have been evaluated and cleared by a pediatric urologist as not having other etiologies of enuresis (e.g. overactive detrusor activity, a genitourinary anatomic abnormality)

Exclusion criteria

✕. Patients with developmental delay or neurologic dysfunction secondary to stroke.
✕. Patients with hypertension or underlying renal disease.
✕. Patients with genitourinary anatomic abnormalities. Any prior renal ultrasound showing normal genitourinary anatomy is sufficient to clear a patient for the study.
✕. Patients with daytime urinary incontinence
✕. Patients with glucosuria on urinalysis.
✕. Patients with secondary nocturnal enuresis who have not been evaluated by a pediatric urologist to rule out other etiologies of enuresis.
✕. Patients who are pregnant.
✕. Patients receiving another medicine for nocturnal enuresis (e.g. imipramine).

What they're measuring

Change in Bedwetting Episodes

Timeframe: Baseline and ~1 month

Trial details

NCT IDNCT04420585

SponsorMontefiore Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-06-12

Results submitted2024-02-22

View on ClinicalTrials.gov More Nocturnal Enuresis trials