Thrombolysis of Urokinase for Minor Stroke (NCT04420351) | Clinical Trial Compass
CompletedPhase 3
Thrombolysis of Urokinase for Minor Stroke
China1,005 participantsStarted 2020-10-04
Plain-language summary
This trial will enroll patients that have been diagnosed with minor stroke, which has occurred within the past 6 hours. TRUST is a prospective multicenter, randomized, blinded-endpoint study to evaluate the efficacy and safety of Urokinase Thrombolysis for patients with minor stroke.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Adult patients: 18-80 years old
. The time from last seen well to treatment \< 6 hours
. Minor stroke defined as a baseline NIHSS ≤5 at the time of randomization..
. First onset or pre-stroke mRS≤1
. Informed consent signed
Exclusion criteria
.Hyperdensity on CT suggesting intracranial hemorrhage
.Large acute stroke \>1/3 middle cerebral artery (MCA) territory visible on CT or MRI
.Other contraindications of intravenous thrombolysis, including but not limited to:
. Intracranial tumor, arteriovenous malformation
. Coma or confirmed as severe stroke by clinical assessment (e.g. NIHSS ≥25) or proper imaging methods
. With seizure
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of patients with a modified Rankin Scale(mRS) of 0 or 1 at 90-day follow-up
Timeframe: 90 Days
2
Proportion of patients with symptomatic intracranial hemorrhage within 36 hours
Timeframe: 36 hours
Trial details
NCT IDNCT04420351
SponsorThe First Affiliated Hospital of Zhengzhou University