Cold EMR Vs Standard EMR for the Treatment of Large Nonpedunculated Homogeneous Colorectal Lesions

Inclusion Criteria: * Patients of age \> 18 years undergoing a colonoscopy for any reason of request and who do not meet exclusion criteria. * Nonpedunculated homogeneous colorectal lesions type LST ( Paris 0-IIa morphology) and serrated lesions larger than 20 mm without endoscopic data of malignancy: NICE 1 pattern +/- NICE 2 component ( serrated lesions) or NICE2 pattern/JNET 2A (adenomas) and therefore subsidiaries of RME. Randomization will be performed per patient, not for colorectal lesions * Signature of informed consent of endoscopic exploration Exclusion Criteria: * .No signature of informed consent prior to the study procedure. * Absence of proper suspension of the anticoagulant/antiplatelet therapy prior to procedure according to usual pre-procedure recommendations (BSG and ESGE guidelines) * Patients with severe thrombopenia/ coagulopathy (Platelets \< 50,000/INR \> 1.5) not corrected prior to procedure (plasma or platelet transfusion) * Patients not candidates for endoscopic resection of colorectal lesions by comorbidities. * Pregnant. * Patients with inflammatory bowel disease (IBD) * Urgent colonoscopy. * Poor preparation (BBPS \<2 in the colon segment where the lesion is located) * Laterally spreading tumors (LST) lesions with non-homogeneous morphology including: sessile polyps (0-Is), pedunculated (0-Ip) and LST lesions with depressed or excavated components (Paris 0-IIc or Paris 0-III), LST granular nodular mixed, LST-G with whole nodular type. In case o…