Oral Hypoglycemic Therapy for Monogenic Variant Carriers of the Joslin Medalist Study

Inclusion Criteria: * Existing participants in the Joslin 50-Year Medalist Study * Residing in the United States * Capable of giving informed consent * Known detectable C-peptide \>0.05 ng/mL Exclusion Criteria: * Known diagnosis of cancer or active inflammatory disease such as rheumatoid arthritis, lupus, and inflammatory bowel disease * Recent history of myocardial infarction, angioplasty, bypass surgery, heart failure, angina, stroke, or uncontrolled hypertension\>160/100 during the past 3 months * Known diagnosis of cognitive dysfunction, dementia or Alzheimer's disease * Pre-existing liver disease or liver function tests (AST or ALT)\>3x the upper limit of normal * Pre-existing kidney disease (Chronic Kidney Disease Stage IV and below, or estimated glomerular filtration rate\<45 mL/min/1.73 m2) * Active use of immunosuppressants * Recipients of prior islet cell or pancreas transplantation * Inability to travel due to frailty or health reasons * Donated blood within the previous two (2) months