Chronic Exertional Compartment Syndrome (CECS) in the lower leg is a debilitating condition in highly active individuals. Pain occurs in 1 or several leg compartments upon an exertional activity, typically running, that quickly dissipates once the activity stopped. Surgical fasciotomy is the standard for treating lower leg CECS, but success is variable. Complications may occur post-surgery and there is a potential for a repeat procedure. Recovery times post-surgery also vary greatly. Conservative treatments, such as gait retraining and botulinum toxin injections, are emerging as non-surgical options for the treatment of CECS with success through published case reports and case series. This study aims to evaluate the use of these non-surgical treatment options for CECS in the anterior and lateral leg compartments with a follow up for at least 2 years across multiple study sites.
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
University of Wisconsin Running Injury and Recovery Index Score at Baseline
Timeframe: baseline
University of Wisconsin Running Injury and Recovery Index Score at 8 Weeks Post-Injection
Timeframe: 8-week
University of Wisconsin Running Injury and Recovery Index Score at 3-months Post-injection
Timeframe: 3-month
University of Wisconsin Running Injury and Recovery Index Score 6-months Post-injection
Timeframe: 6-month
University of Wisconsin Running Injury and Recovery Index Score at 12-months Post-Injection
Timeframe: 12-month
University of Wisconsin Running Injury and Recovery Index Score at 24-Months Post-Injection
Timeframe: 24-month
Single Assessment Numerical Evaluation (SANE) Score at Baseline
Timeframe: baseline
Single Assessment Numerical Evaluation (SANE) 8-weeks Post-Injection
Timeframe: 8-weeks
Single Assessment Numerical Evaluation (SANE) at 3-months Post-Injection
Timeframe: 3-months
Single Assessment Numerical Evaluation (SANE) at 6-months Post-Injection
Timeframe: 6-months
Single Assessment Numerical Evaluation (SANE) at 12-months Post-Injection
Timeframe: 12-months
Single Assessment Numerical Evaluation (SANE) at 24-months Post-Injection
Timeframe: 24-months
Global Rate of Change Score at 8-weeks Post-Injection
Timeframe: 8-weeks
Global Rate of Change Score 3-months Post-Injection
Timeframe: 3-months
Global Rate of Change Score at 6-months Post-Injection
Timeframe: 6-months
Global Rate of Change Score 12-months Post-Injection
Timeframe: 12-months
Global Rate of Change Score at 24-months Post-Injection
Timeframe: 24-months
Duty Status at Baseline
Timeframe: baseline
Duty Status at 8-weeks Post-Injection
Timeframe: 8-weeks
Duty Status at 3-months Post-Injection
Timeframe: 3-months
Duty Status at 6-months Post-Injection
Timeframe: 6-months
Duty Status at 12-months Post-Injection
Timeframe: 12-months
Duty Status at 24-months Post-Injection
Timeframe: 24-months
Patient Specific Functional Scale Scores at Baseline
Timeframe: baseline
Patient Specific Functional Scale Scores at 8-weeks Post-Injection
Timeframe: 8-weeks
Patient Specific Functional Scale Scores at 3-months Post-Injection
Timeframe: 3-months
Patient Specific Functional Scale Scores at 6-months Post-Injection
Timeframe: 6-months
Patient Specific Functional Scale Scores at 12-months Post-Injection
Timeframe: 12-months
Patient Specific Functional Scale Scores at 24-months Post-Injection
Timeframe: 24-months
Balance Error Scoring System Score at Baseline
Timeframe: baseline
Balance Error Scoring System Score at 8-weeks Post-Injection
Timeframe: 8-weeks
Balance Error Scoring System Score at 3-months Post-Injection
Timeframe: 3-months
Balance Error Scoring System Score at 6-months Post-Injection
Timeframe: 6-months
Balance Error Scoring System Score at 12-months Post-Injection
Timeframe: 12-months
Gait Analysis - Cadence at Baseline
Timeframe: Baseline
Ability to Run 2 Miles at Baseline
Timeframe: baseline
Ability to Run 2 Miles at 8-weeks Post-Injection
Timeframe: 8-weeks
Ability to Run 2 Miles at 3-months Post-Injection
Timeframe: 3-months
Ability to Run 2 Miles at 6-months Post-Injection
Timeframe: 6-months
Ability to Run 2 Miles at 12-months Post-Injection
Timeframe: 12-months
Ability to Run 2 Miles at 24-months Post-Injection
Timeframe: 24-months
Gait Analysis - Cadence at 8-weeks Post-Injection
Timeframe: 8-Weeks
Gait Analysis - Cadence at 3-months Post-Injection
Timeframe: 3-months
Gait Analysis - Cadence at 6-months Post-Injection
Timeframe: 6-months
Gait Analysis - Cadence at 12-months Post-Injection
Timeframe: 12-months