Alvimopan as a Rescue Treatment of Postoperative Ileus

Inclusion Criteria: * 1\. Subjects who have benign or malignant colonic or rectal disease that have undergone laparoscopic or open colorectal resection, small bowel resection or ileostomy reversal with small bowel resection and subsequently developed postoperative ileus, defined as: a. Patients with symptoms of bloating with or without nausea and vomiting, with absence of passage of flatus or stool who require either i. Return to NPO status after initial diet attempts ii. Undergo placement of a nasogastric tube b. Patients with absence of passage of flatus or stool who are either i. More than 5 days after open surgery without recovery of GI function ii. More than 3 days after laparoscopic surgery or ileostomy closure without recovery of GI function 2\. Subjects who are 18 years of age and older 3\. Subjects of either gender 4\. Subjects who are willing and able to adhere to protocol requirements, agree to participate in the study program and provide written and informed consent. Exclusion Criteria: * 1\. Subjects who received Alvimopan preoperatively. 2\. Subjects that have taken therapeutic doses of opioids for more than 7 days immediately prior to surgery. 3\. Subjects with severe hepatic impairment. 4\. Subjects with end-stage renal disease. 5\. Subjects who are pregnant. 6\. Subjects who have undergone imaging suggesting a small bowel obstruction. 7\. Subjects with a medical condition that may interfere with the use of the study medicatio…