The use of a mixture of helium with oxygen (heliox) as a breathing gas may be beneficial due to its unique physical properties, such as low density and high carbon dioxide (CO2) diffusion coefficient. In previous studies in neonates with respiratory failure, conventional ventilation with heliox was associated with improved oxygenation and selected respiratory parameters. The use of heliox may increase the effectiveness of intermittent nasal positive pressure ventilation (NIPPV), but knowledge about the effects of such therapy on newborns is limited.The use of non- invasive neurally adjusted ventilatory assist (NIV-NAVA) allows synchronization and assessment of electrical activity of the diaphragm (EaDI) during heliox administration in premature babies with respiratory failure.
Age range
1 Hour
Sex
ALL
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baseline minimal electric activity of the diaphragm (EaDI min)
Timeframe: measured at baseline
baseline mean electric activity of the diaphragm (EaDI mean)
Timeframe: measured at baseline
baseline maximal electric activity of the diaphragm (EaDI max)
Timeframe: measured at baseline
minimal electric activity of the diaphragm (EaDI min) after 15 minutes of heliox
Timeframe: measured after 15 minutes of heliox ventilation
mean electric activity of the diaphragm (EaDI mean) after 15 minutes of heliox
Timeframe: measured after 15 minutes of heliox ventilation
maximal electric activity of the diaphragm (EaDI max) after 15 minutes of heliox
Timeframe: measured after 15 minutes of heliox ventilation
minimal electric activity of the diaphragm (EaDI min) after 60 minutes of heliox
Timeframe: measured after 60 minutes of heliox ventilation
mean electric activity of the diaphragm (EaDI mean) after 60 minutes of heliox
Timeframe: measured after 60 minutes of heliox ventilation
maximal electric activity of the diaphragm (EaDI max) after 60 minutes of heliox
Timeframe: measured after 60 minutes of heliox ventilation
minimal electric activity of the diaphragm (EaDI min) after 180 minutes of heliox
Timeframe: measured after 180 minutes of heliox ventilation
mean electric activity of the diaphragm (EaDI mean) after 180 minutes of heliox
Timeframe: measured after 180 minutes of heliox ventilation
maximal electric activity of the diaphragm (EaDI max) after 180 minutes of heliox
Timeframe: measured after 180 minutes of heliox ventilation
minimal electric activity of the diaphragm (EaDI min) after 15 minutes of standard mixture
Timeframe: measured after 15 minutes since the return to ventilation with standard mixture
mean electric activity of the diaphragm (EaDI mean) after 15 minutes of standard mixture
Timeframe: measured after 15 minutes since the return to ventilation with standard mixture
maximal electric activity of the diaphragm (EaDI max) after 15 minutes of standard mixture
Timeframe: measured after 15 minutes since the return to ventilation with standard mixture
minimal electric activity of the diaphragm (EaDI min) after 60 minutes of standard mixture
Timeframe: measured after 60 minutes since the return to ventilation with standard mixture
mean electric activity of the diaphragm (EaDI mean) after 60 minutes of standard mixture
Timeframe: measured after 60 minutes since the return to ventilation with standard mixture
maximal electric activity of the diaphragm (EaDI max) after 60 minutes of standard mixture
Timeframe: measured after 60 minutes since the return to ventilation with standard mixture
minimal electric activity of the diaphragm (EaDI min) after 180 minutes of standard mixture
Timeframe: measured after 180 minutes since the return to ventilation with standard mixture
mean electric activity of the diaphragm (EaDI mean) after 180 minutes of standard mixture
Timeframe: measured after 180 minutes since the return to ventilation with standard mixture
maximal electric activity of the diaphragm (EaDI max) after 180 minutes of standard mixture
Timeframe: measured after 180 minutes since the return to ventilation with standard mixture
baseline PIP (peak inspiratory pressure)
Timeframe: measured at baseline
baseline PEEP (positive end-expiratory pressure)
Timeframe: measured at baseline
baseline MAP (mean airway pressure)
Timeframe: measured at baseline
PIP (peak inspiratory pressure) after 15 minutes of heliox
Timeframe: measured after 15 minutes of heliox ventilation
PIP (peak inspiratory pressure) after 60 minutes of heliox
Timeframe: measured after 60 minutes of heliox ventilation
PIP (peak inspiratory pressure) after 180 minutes of heliox
Timeframe: measured after 180 minutes of heliox ventilation
PIP (peak inspiratory pressure) after 15 minutes of standard mixture
Timeframe: measured after 15 minutes since the return to ventilation with standard mixture
PIP (peak inspiratory pressure) after 60 minutes of standard mixture
Timeframe: measured after 60 minutes since the return to ventilation with standard mixture
PIP (peak inspiratory pressure) after 180 minutes of standard mixture
Timeframe: measured after 180 minutes since the return to ventilation with standard mixture
PEEP (positive end-expiratory pressure) after 15 minutes of heliox
Timeframe: measured after 15 minutes of heliox ventilation
PEEP (positive end-expiratory pressure) after 60 minutes of heliox
Timeframe: measured after 60 minutes of heliox ventilation
PEEP (positive end-expiratory pressure) after 180 minutes of heliox
Timeframe: measured after 180 minutes of heliox ventilation
PEEP (positive end-expiratory pressure) after 15 minutes of standard mixture
Timeframe: measured after 15 minutes since the return to ventilation with standard mixture
PEEP (positive end-expiratory pressure) after 60 minutes of standard mixture
Timeframe: measured after 60 minutes since the return to ventilation with standard mixture
PEEP (positive end-expiratory pressure) after 180 minutes of standard mixture
Timeframe: measured after 180 minutes since the return to ventilation with standard mixture
MAP (mean airway pressure) after 15 minutes of heliox
Timeframe: measured after 15 minutes of heliox ventilation
MAP (mean airway pressure) after 60 minutes of heliox
Timeframe: measured after 60 minutes of heliox ventilation
MAP (mean airway pressure) after 180 minutes of heliox
Timeframe: measured after 180 minutes of heliox ventilation
MAP (mean airway pressure) after 15 minutes of standard ventilation
Timeframe: measured after 180 minutes since the return to ventilation with standard mixture
MAP (mean airway pressure) after 60 minutes of standard ventilation
Timeframe: measured after 60 minutes since the return to ventilation with standard mixture
MAP (mean airway pressure) after 180 minutes of standard ventilation
Timeframe: measured after 180 minutes since the return to ventilation with standard mixture
baseline NIV leakage
Timeframe: measured at baseline
NIV leakage after 15 minutes of heliox
Timeframe: measured after 15 minutes of heliox ventilation
NIV leakage after 60 minutes of heliox
Timeframe: measured after 60 minutes of heliox ventilation
NIV leakage after 180 minutes of heliox
Timeframe: measured after 180 minutes of heliox ventilation
NIV leakage after 15 minutes of standard mixture
Timeframe: measured after 15 minutes since the return to ventilation with standard mixture
NIV leakage after 60 minutes of standard mixture
Timeframe: measured after 60 minutes since the return to ventilation with standard mixture
NIV leakage after 180 minutes of standard mixture
Timeframe: measured after 180 minutes since the return to ventilation with standard mixture