Sentinel Lymph Node Mapping in Esophageal Cancer Using ICG Dye and NIR Imaging (NCT04400292) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Sentinel Lymph Node Mapping in Esophageal Cancer Using ICG Dye and NIR Imaging
United States90 participantsStarted 2020-05-20
Plain-language summary
The purpose of this study is to find out whether sentinel lymph node (SLN) mapping with ICG dye and NIR imaging can be used to identify esophageal or esophagogastric junction cancer that has spread to the lymph nodes. If SLN mapping is successful in these types of cancer, surgeons in the future could identify the sentinel lymph nodes and only remove these instead of removing all the lymph nodes which is currently done.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Pathological diagnosis of adenocarcinoma tumor located in distal 1/3 of esophagus or esophagogastric junction , with a plan to undergo minimally invasive esophagectomy.
* All patients with Stage IVA (AJCC Cancer Staging Manual, 8th edition) disease will be eligible
* ≥18 years of age.
* Documented, signed, and dated informed consent, obtained before any procedures, for the proposed research study and for standard surgical resection.
Exclusion Criteria:
* No plan to undergo surgical resection.
* Severe iodide or seafood allergy.
* Women of childbearing potential without a negative pregnancy test; or women who are lactating.
* Prior diagnosis of severe hepatic or renal dysfunction.
* Patients with Stage IVB or M1 disease (AJCC Cancer Staging Manual, 8th edition)
* Patients with local recurrence and planning to undergo salvage esophagectomy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The number of lymph nodes visualized to be fluorescent and nonfluorescent.