Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3

Inclusion Criteria: * Age between 18 and 85 years old. * Genetically confirmed SCA 3 diagnosis. * Presence of progressive cerebellar syndrome (i.e. symptomatic) and genetic confirmation of SCA 3 in one of the immediate family members with similar clinical syndrome. * Able to read, speak, and understand English or Malay. Exclusion Criteria: * Diagnosis of Diabetes Mellitus Type 1 or Type 2 * Presence of any concomitant neurological condition that might interfere with clinical measures used in this study. * Presence of contraindication or hypersensitivity to trehalose. * Use of stimulant / medication, caffeine, and tobacco within less than 24 hours washout period prior to assessment and / or scan. * Presence of severe visual and / or auditory perceptual deficits. * MRI contra-indications: claustrophobia, pregnancy, electronic implants (e.g. pacemaker) in the body, aneurysm clip, and current or past employment as machinists, welders or metal workers.