Effects of Combination Exercise on Fatigability in Veterans With Chronic Kidney Disease

Inclusion Criteria: * Ambulatory (with or without a gait aid), 50 years of age or older diagnosed with chronic kidney disease (CKD) stages 3 \& 4 predialysis (as defined by eGFR 59-15 ml/min per 1.73m2) * Control group will include ambulatory individuals without clinical evidence of kidney disease (defined by eGRF \>60 ml/min per 1.73m2) within the last 12-months * All participants must be able to speak and read English, and demonstrate orientation to person, place, and time Exclusion Criteria: * adults diagnosed with acute renal failure/injury within the last 12-months * non-ambulatory individuals * adults who do not use the DC VAMC as their main site for renal care * those who have any uncontrolled cardiovascular * musculoskeletal disease * or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe * any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol * additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study