RecruitingNot Applicable

Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate

Canada20 participantsStarted 2021-08-11

Plain-language summary

The investigators will seek to determine the relationship between heart rate and middle cerebral artery (MCA) cerebral blood flow (CBF), as well as better understand the hemodynamic determinants of MCA CBF velocity. In order to manipulate heart rate, the investigators will recruit patients already scheduled for clinically indicated elective electrophysiological studies, where temporary pacing catheters placed in the right atrium can be used to artificially pace the heart at controlled rates. MCA CBF will be measured by transcranial Doppler ultrasound.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male or female * Age 18-70 years, inclusive * Scheduled for clinically indicated elective electrophysiological studies where temporary pacing catheters are being placed in the right atrium * Left ventricular ejection fraction ≥50% * Able and willing to provide informed consent * Able to travel to the Cardiac Electrophysiology Laboratory at the Foothills Medical Centre, Calgary, Alberta, Canada Exclusion Criteria: * Unable or unwilling to provide informed consent * Other factors which in the investigator's opinion would prevent the participant from completing the protocol

What they're measuring

Change in MCA CBF velocity in response to high right atrial pacing at 400 ms (150 bpm) relative to baseline while in the supine position

Timeframe: After 1 minute of pacing at 400 ms (150 bpm)

Trial details

NCT IDNCT04391465

SponsorUniversity of Calgary

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

Contact for this trial

Satish R Raj, MD MSCI

403-210-6152 satish.raj@ucalgary.ca