CompletedNot Applicable

Treatment of Patients With Periorbital Hyperpigmentation

Egypt31 participantsStarted 2020-02-12

Plain-language summary

Periorbital hyperpigmentation (POH) is a common condition in dermatology practice. Periorbital hyperpigmentation is defined as bilateral, round, homogeneous pigmented macules.The etiology of POH is multifactorial including genetic and enviromental factors. Many treatment options are avaiblabe with variable efficacy and safety in different patients. Therefore, the investigator's study aims to evaluate the efficacy and safety of combined microneedling with topical Glutathione versus Carboxy Therapy in treatment of patients with periorbital hyperpigmentation.

Who can participate

Age range

18 Years – 65 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with Periorbital hyperpigmentation Exclusion Criteria: * Pregnancy and lactation . * Allergy, hypersensitivity to the formulations to be used in the study. * Any other cutaneous or systemic disease. * Patient who had taken any other treatment (laser, dermabrasion) on the affected region performed less than 6 months prior to the beginning of the study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change of periorbital hyperpigmentation through photo evaluation

Timeframe: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment

Change of periorbital hyperpigmentation through dermoscopy evaluation

Timeframe: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment

Change of the patient satisfaction evaluation: scale

Timeframe: Baseline and 1 month after end of treatment

Change of periorbital hyperpigmentation into another skin problem through safety evaluation

Timeframe: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment

Trial details

NCT IDNCT04389788

SponsorSohag University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-10-10

View on ClinicalTrials.gov More Periorbital Hypermelanosis trials

Plain-language summary

Who can participate

Age range

18 Years – 65 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change of periorbital hyperpigmentation through photo evaluation

Timeframe: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment

Change of periorbital hyperpigmentation through dermoscopy evaluation

Timeframe: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment

Change of the patient satisfaction evaluation: scale

Timeframe: Baseline and 1 month after end of treatment

Change of periorbital hyperpigmentation into another skin problem through safety evaluation

Timeframe: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment