Periorbital hyperpigmentation (POH) is a common condition in dermatology practice. Periorbital hyperpigmentation is defined as bilateral, round, homogeneous pigmented macules.The etiology of POH is multifactorial including genetic and enviromental factors. Many treatment options are avaiblabe with variable efficacy and safety in different patients. Therefore, the investigator's study aims to evaluate the efficacy and safety of combined microneedling with topical Glutathione versus Carboxy Therapy in treatment of patients with periorbital hyperpigmentation.
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Change of periorbital hyperpigmentation through photo evaluation
Timeframe: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment
Change of periorbital hyperpigmentation through dermoscopy evaluation
Timeframe: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment
Change of the patient satisfaction evaluation: scale
Timeframe: Baseline and 1 month after end of treatment
Change of periorbital hyperpigmentation into another skin problem through safety evaluation
Timeframe: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment