CompletedNot Applicable

Determination of Circulating Placental Biomarkers Levels to Predict the Pregnancy Outcome of First Trimester After IVF.

Portugal120 participantsStarted 2020-06-12

Plain-language summary

This study will assess the predictive potential of circulating placental biomarkers for spontaneous miscarriage within the following month in an IVF setting. It is hypothesized that a robust algorithm including one or more of these biomarkers may allow for the accurate same-day distinction between women with a low and high risk of a spontaneous miscarriage.

Who can participate

Age range18 Years – 48 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: ≥18 and \<49 years old * Body Mass Index (BMI): ≥18.5 Kg/m2 and \<30 Kg/m2 * Pregnancy resulting from Assisted Reproductive Technologies (ART) * Single blastocyst transfer pregnancy * Pregnancy confirmed by blood test * Gestational age \< 6 weeks at the first US * Signed and dated informed consent Exclusion Criteria: * Spontaneous pregnancies * Treatment for prevention of miscarriage (i.e. corticoids, aspirin, heparin) * Those unable to provide the 11th-13th week ultrasound report * Those unable to comprehend the investigational nature of the proposed study

What they're measuring

Pregnancy outcome (spontaneous miscarriage versus evolutive pregnancy) at the first trimester ultrasound

Timeframe: Up to the first trimester ultrasound (11 to 13 weeks plus 6 days of gestation)

Trial details

NCT IDNCT04387994

SponsorInstituto Valenciano de Infertilidade de Lisboa

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2021-12-07

View on ClinicalTrials.gov More Infertility, Female trials