CompletedNot Applicable

Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia

United States120 participantsStarted 2021-05-12

Plain-language summary

The investigators will attempt to develop a more accurate equation to estimate eGFR in pediatric and adult sickle cell patients

Who can participate

Age range5 Years – 50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * SCA patients (HbSS and SB0 thalassemia) * Age: 5.0-50.0 at enrollment Exclusion Criteria: * Recent SCA complication associated with hospitalization (within 30 days) or ED visit (within 14 days) * Current AKI defined as \>0.3mg/g increase in SCr from prior visit * Known history of anaphylaxis with contrast agent or known pregnancy

What they're measuring

To develop a novel SCA-specific eGFR equation and compare with existing eGFR equations validated for the general population

Timeframe: 5 years

Trial details

NCT IDNCT04380610

SponsorUniversity of Alabama at Birmingham

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-30

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