Effects of Pregnancy-associated Hormones on THC Metabolism in Women

Inclusion Criteria: * Healthy, premenopausal women ages 21-45 years old * Body mass index (BMI) \<30 kg/m2 * Regular menstrual periods (monthly, cycle 28-35 days in length) * Willingness to use nonhormonal methods of contraception during the study period Exclusion Criteria: * History of diabetes or significant cardiac, kidney (eGFR\<60 mL/min/1.73m2), gastrointestinal or liver disease * History of blood clots or stroke * Allergy to dronabinol, synthetic steroids, or any other chemically related drug or steroid * Current or recent ingestion (\<3 weeks) of any medication or herbal supplement known to be an inducer or inhibitor of CYP2C9, CYP3A4 or UGT. These include some anticoagulants, anti-psychotics, antibiotics, antifungal agents, antidepressants, anti-retroviral agents and herbal supplements (or other over-the-counter medications and supplements). Subjects who are taking any of these prescription drugs will not be asked to discontinue treatment but will be ineligible for study participation. Subjects taking excluded over-the-counter medications and/or supplements will be given the option of discontinuing these for 1 month prior to study participation. * Current pregnancy or lactation * History of use of illicit drugs or smoking within the last year * Any recreational or medicinal use of cannabis or other forms of THC within 3 months * Current use of amphetamines, anticholinergic drugs or antidepressants * History of seizure disorder or psychiatric illness (mania or schi…