Stopped: Study proposal was not accepted for funding and therefore not further explored at this stage.
The investigator hypothesizes that oxidative stress responses to West Nile virus infection in the central nervous system determine the severity of infection and the long-term neurological, neuropsychological and functional sequelae of West Nile Neuroinvasive Disease.
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Measure the redox status
Timeframe: at recruitment, 10 days post-symptom onset and 20 days post symtom onset.
Assessment of Neurologic deficits
Timeframe: At recruitment, month 3 and month 12
Neuropsychologic performance
Timeframe: 20 days post-symtom onset, month 3 and month 12
Longitudinal assessment of functional status Study the neurologic and neuropsychologic sequelae of WNV infection during a 12-month followup period.
Timeframe: at recruitment, month 3 and month 12
MRI abnormalities
Timeframe: at recruitment, month 3 and month 12
Brain iron content
Timeframe: at recruitment, month 3 and month 12
Ophthalmological abnormalities
Timeframe: at recruitment, with a follow-up of clinically indicated.
serum S100b concentration
Timeframe: at recruitment, 10 days post symptom onset and 20 days post symptom onset
serum NSE concentration
Timeframe: at recruitment, 10 days post symptom onset and 20 days post symptom onset