CompletedNot Applicable

Investigate the Mechanisms, Predictors, and Prevention of Persistent Post-Traumatic Headache

United States101 participantsStarted 2020-09-09

Plain-language summary

This is a United States Department of Defense funded Focused Program study that aims to identify mechanisms and predictors for persistent of post-traumatic headache attributed to mild traumatic brain injury, and identify methods of preventing post-traumatic headache persistence

Who can participate

Age range

18 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

. Metal implants
. Aneurysm clips
. Severe claustrophobia
. Implanted electronic devices
. Insulin or infusion pump
. Cochlear/otologic/ear implant
. Non-removable prosthesis
. Implanted shunts/catheters

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial has already been completed and was studying what causes post-traumatic headaches to become persistent — has any data or findings from this study been published yet, and could they help us understand my situation?
2Since this trial tracked things like brain MRI changes and blood biomarkers over time to look for patterns in post-traumatic headache, are any of those same tests something we should consider doing for me to better understand what's driving my headaches?
3The trial looked at sensitivity to light and skin pain thresholds as possible markers — do my symptoms line up with the kinds of patterns they were investigating, and does that change how you'd approach my treatment?
4Because this was an observational study focused on understanding mechanisms rather than testing a treatment, what does the research it uncovered actually suggest about my options for managing or preventing persistent post-traumatic headache?
5Are there any follow-up trials or treatment studies that grew out of this research that might be worth looking into, given that this one has already completed?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.