Influenza Vaccination, ACEI and ARB in the Evolution of SARS-CoV2 Infection (NCT04367883) | Clinical Trial Compass
RecruitingNot Applicable
Influenza Vaccination, ACEI and ARB in the Evolution of SARS-CoV2 Infection
Spain3,000 participantsStarted 2020-03-01
Plain-language summary
Some authors have proposed the use of the flu vaccine to reduce the severity of COVID-19 cases, while some have proposed the use of ACE Inhibitors (ACEI) or Angiotensin Receptor blockers (ARB), since this virus shares hemagglutinin as a transmission mechanism and acts on the ACE2 enzyme during infection.
Other authors described how none of the elderly patients receiving antihistamines and azythromycin in two nursing homes in Toledo -Spain- during the first wave died or needed hospital admission, even considering that 100% of residents had a positive serological test after that wave. Other authors have described a positive evolution in patients receiving amantadine for their Parkinson's disease.
The aim is to evaluate whether the admitted patients who are previously vaccinated or those who were already receiving these treatments showed a better evolution.
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Hospital Admissions at the Hospital of Terrassa from March 1, 2020 for any cause.
Exclusion Criteria:
* None.
* For comparison of percentage of Influenza vaccination, ACEI and ARB vs general population, patients from outside the reference area of the Terrassa Health Consortium would be excluded.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is looking at how influenza vaccination, ACE inhibitors, ARBs, antihistamines, and amantadine relate to how COVID-19 plays out — if I'm already taking an ACE inhibitor or ARB for blood pressure or heart issues, could my current medications affect whether this trial would be relevant to my situation?
2The trial is listed as 'Phase NA,' which often means it's observational rather than testing a new treatment — can you help me understand whether this study would involve any changes to my current medications or if it's mainly tracking outcomes based on what I'm already taking?
3Since the main thing being measured is 'hospital output,' does that mean this study is focused on whether certain medications or vaccination history affect the chances of being hospitalized with COVID-19, and how might that information be useful for my own care decisions?
4The trial includes amantadine, which is an antiviral sometimes used for flu — is there anything about my current health history that would make it worth discussing whether amantadine plays any role in my COVID-19 treatment plan, separate from this trial?
5Given that this trial is still recruiting, would enrolling in it delay, replace, or run alongside any standard COVID-19 treatment options you'd recommend for me right now?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.