Impact of a Intra-tracheal Intubation With Curarization or Without Curarization (NCT04364633) | Clinical Trial Compass
TerminatedNot Applicable
Impact of a Intra-tracheal Intubation With Curarization or Without Curarization
Stopped: Premature termination of the study because it was dependent on the Remicrush study which ended more quickly, not allowing the inclusion of the expected number of patients.
France7 participantsStarted 2020-06-16
Plain-language summary
VHIntubation is a French monocentric and observational study that will assess the impact of two intra-tracheal intubation preparation procedures (curarization versus remifentanil) on the voice, using the Voice Handicap Index (VHI) self-questionnaire.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Patients included in " REMICRUSH " study
* patient's non-opposition to participation in research
Inclusions criteria in REMICRUSH are :
* male or female aged from 18 to 80 years old
* surgery requiring general anaesthesia with tracheal with oro-tracheal intubation
* Rapid sequence intubation indication
* aspiration risk defined as : fasting \< 6h00, digestive occlusion, functional ileus, vomiting \< 12h00, orthopaedic trauma \< 12h00, severe gastric reflux, gastroparesis and/or dysautonomia and or gastro-oesophagus surgery
* signed informed consent sheet ; or emergency procedure if impossible
Exclusion Criteria:
* Patients non-included in " REMICRUSH " study
* Patients with cervical surgery
* Patient declines to participate in research
Exclusion criteria in REMICRUSH are :
* planned impossible intubation
* suspected/known allergy to neuromuscular blockade or remifentanil
* neuromuscular disease forbidding neuromuscular blockade use
* Prolonged neuromuscular block former episode
* Malignant hyperthermia former episode
* Pre-operative respiratory failure (spO2\< 95%)
* Pre-operative hemodynamic failure (use of vasopressor) cardiac arrest
* A woman of childbearing age who has an active pregnancy and/or clinical signs suggestive of an active pregnancy and/or does not have a contraceptive or contraceptive method and has had unprotected sex within 15 days of the last menstrual period.
* Patients under justice protection
* Use of etomidate for anesthetic…