Increased D-dimers at admission of COVID-19 infected patients entering hospital due to a severe disease is a risk factor for death. Understanding this acquired coagulopathy is a prerequisite before specific interventional studies. The study investigators aim to apply a normalized and automated thrombin generation test (TGT), developed for testing the thrombotic risk (triggered by 5 pM Tissue Factor, with a purified thrombomodulin (TM) challenge) and to study its association with survival.
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28-day survival rate
Timeframe: 1 month
Absolute thrombin generation test latent period
Timeframe: Day 0
Relative thrombin generation test latent period compared to reference plasma
Timeframe: Day 0
Absolute thrombin generation test initial velocity
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Relative thrombin generation test initial velocity compared to reference plasma
Timeframe: Day 0
Relative thrombin generation test peak thrombin compared to reference plasma
Timeframe: Day 0
Absolute thrombin generation test peak thrombin
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Absolute thrombin generation test peak thrombin time
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Relative thrombin generation test peak thrombin time compared to reference plasma
Timeframe: Day 0
Absolute thrombin generation test total thrombin generation time
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Relative thrombin generation test total thrombin generation time compared to reference plasma
Timeframe: Day 0
Absolute thrombin generation test endogenous thrombin potential
Timeframe: Day 0
Relative thrombin generation test endogenous thrombin potential compared to reference plasma
Timeframe: Day 0