The Acute Burn ResUscitation Multicenter Prospective Trial

Inclusion Criteria: * Age ≥ 18 years * Total burn size (second and third degree) is ≥ 25% of the TBSA * Burn center admission within 12 hours of injury. * There is a plan for formal fluid resuscitation. Exclusion Criteria: * Significant associated trauma * High voltage (≥ 1000 volts) electrical burns * Burn wound excision surgery within 48 hours from injury * Fresh frozen plasma (FFP) given at any time ≤ 48 hours from injury * Hypertonic saline (HTS) given at any time ≤ 48 hours from injury * Hydroxyethyl starch (HES) given at any time ≤ 48 hours from injury * High dose Vitamin C infusion given at any time ≤ 48 hours from injury * Administration of human albumin prior to randomization * Palliative comfort measures are instituted ≤ 48 hours from injury * Pregnancy * Pre-injury chronic renal insufficiency equal to or greater than stage 3 * Pre-injury chronic hepatic disease (Child-Pugh B or C) * Pre-injury left ventricular (LV) dysfunction (echocardiography LV grade II-IV or ejection fraction ≤ 35%)