CompletedNot Applicable

The Acute Burn ResUscitation Multicenter Prospective Trial

United States, Canada101 participantsStarted 2021-04-22

Plain-language summary

This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Total burn size (second and third degree) is ≥ 25% of the TBSA * Burn center admission within 12 hours of injury. * There is a plan for formal fluid resuscitation. Exclusion Criteria: * Significant associated trauma * High voltage (≥ 1000 volts) electrical burns * Burn wound excision surgery within 48 hours from injury * Fresh frozen plasma (FFP) given at any time ≤ 48 hours from injury * Hypertonic saline (HTS) given at any time ≤ 48 hours from injury * Hydroxyethyl starch (HES) given at any time ≤ 48 hours from injury * High dose Vitamin C infusion given at any time ≤ 48 hours from injury * Administration of human albumin prior to randomization * Palliative comfort measures are instituted ≤ 48 hours from injury * Pregnancy * Pre-injury chronic renal insufficiency equal to or greater than stage 3 * Pre-injury chronic hepatic disease (Child-Pugh B or C) * Pre-injury left ventricular (LV) dysfunction (echocardiography LV grade II-IV or ejection fraction ≤ 35%)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Volume of fluid received during resuscitation for burn injury

Timeframe: 24 hours post burn injury

Trial details

NCT IDNCT04356859

SponsorAmerican Burn Association

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-09-29

View on ClinicalTrials.gov More Burn Injury trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.