CompletedNot Applicable

Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure

Argentina80 participantsStarted 2018-10-01

Plain-language summary

Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated. The maximum expiratory pressure measured in the usual way and the maximum expiratory pressure generated during the induced cough were taken as predictor variables. The outcome variable was extubation failure, measured at 72 hours and at 7 days.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Under mechanical ventilation via endotracheal tube in a period greater than 48 hours * Passing the spontaneous breathing trial an be ready for extubation. * Agree to participate in the study and sign the informed consent by the patient or family member Exclusion Criteria: * tracheostomized prior to admission to mechanical ventilation * history of neuromuscular disease * presence of unstable heart disease * received upper digestive surgery * presence of uncontained enterocutaneous fistula * candidates for non-invasive ventilation as a modality of interface exchange for extubation or as a preventive modality * patients who did not reach a MEP (habitual) of 30 cmH20 since they are not extubated by the extubation protocol of our institution.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Extubation failure

Timeframe: 72 hours

Extubation failure

Timeframe: 7 days

Trial details

NCT IDNCT04356625

SponsorHospital Nacional Profesor Alejandro Posadas

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-09-01

View on ClinicalTrials.gov More Airway Extubation trials