Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain (NCT04356352) | Clinical Trial Compass
TerminatedPhase 2/3
Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain
Stopped: feasibility of enrollment
United States33 participantsStarted 2020-09-09
Plain-language summary
The primary hypothesis is that esmolol and lidocaine, when given without the use of a tourniquet, provide relief of propofol injection pain that is superior to placebo when assessed using the propofol pain scoring tool
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 18-60 years of age
* ASA 1-3
* Elective surgical procedure
Exclusion Criteria:
* BMI ≥ 45
* Pregnancy
* Requirement for RSI or awake intubation
* Suspected or known difficult airway
* Contraindication to IV in either upper extremity
* Chronic pain syndrome including fibromyalgia
* Use of opioids, NSAIDs, or other analgesics within 24 hours (including preoperative PO Celebrex, Lyrica, Tylenol, etc.)
* Any use of opioids in the past three months
* Significant cardiopulmonary or hepatic dysfunction
* Hypersensitivity to study medications
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Patient Pain Score
Timeframe: following administration of a sub-induction dose of propofol, 0.5 mg/kg up to 50 mg, just prior to full induction