Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections

Inclusion Criteria: * all adult patients (≥ 18 years old) hospitalized for a complicated community acquired pleural infection at University Hospital Amiens-Picardie. * Complicated pleural infection is defined by the presence of one of the following criteria: frank pus, loculated pleural fluid, presence of organisms identified by Gram stain and/or culture from a non-purulent pleural fluid sample, pleural fluid pH \<7.2, pleural fluid glucose \<0.32g/l or large non-purulent effusion. Exclusion Criteria: * non-infectious pleural effusion * hospital-acquired pleural infection * patient treated with amoxicillin and clavulanic acid (if treatment was started more than \> 24h ago) * Minors, pregnant women, adult patients protected by law. * Pleural infection requiring instant thoracic surgery * allergy to beta-lactam * Injection of contrast agent (Iomeron or Iohexol) during the 24 hours preceding or following the first dose of amoxicillin / clavulanic acid.