SARS-CoV2 has become a pandemic disease putting an enormous burden on health care systems around the world. A considerable amount of patients require intensive care treatment for Covid-19 associated pneumonia. At this point there is no specific treatment, apart from supportive intensive care treatment protocols for severe COVID-19 disease.The latest reports describe massive hyperinflammation in some of the severe COVID-19 patients, which is not a typical finding in virus associated pneumonia. The H-score and the modified HLH 2004 score offer diagnostic tools, that help establishing the diagnosis of HLH. Even more important is the expert clinical judgment to establish the diagnosis of sHLH.
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Presence of sHLH as determined by expert chart review by two independent reviewers
Timeframe: in the first week after admission to the ICU
Determine the incidence of patients fulfilling HLH criteria in Covid 19 viral infection
Timeframe: in the first week after admission to the ICU
Determine the incidence of patients fulfilling modified 2004 HLH diagnostic criteria (Ferritin > 10000 ÎĽg/L) in Covid 19 viral infection
Timeframe: in the week after admission to the ICU
Characterization and incidence of the hyper-inflammatory state in COVID-19
Timeframe: assessed within 15 days post ICU-admission