SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)

Inclusion Criteria: * Adults of 18 years or older * Patients hospitalized with a diagnosis of COVID-19 based on central laboratory-confirmed COVID-19 Novel Coronavirus Disease-2019, based on a positive SARS-CoV-2 RT-PCR confirmed within 72 hours prior to enrollment of nasal, oropharyngeal, or BAL specimen with hypoxemia, (i.e., decrease in oxygenation, as outlined below) * Pulse oximetry saturation (SpO2) \< 93% on room air in WHO COVID-19 ordinal scale 3 patients, regardless the need for assisted ventilation, or oxygenation. * Any new requirement of supplemental oxygen, with any oxygen device (WHO COVID-19 ordinal scale 4-7, regardless of pulse oximetry reading) * In patients with supplemental oxygen at home, any increase in the requirement of supplemental oxygen. * In ICU level care Exclusion Criteria: * Age less than 18 years * Known allergy to Vitamin C * Inability to obtain consent from patient or next of kin * Presence of diabetic ketoacidosis * ANY history of oxalate stones at any time * Patients with Kidney Disease Improving Global Outcomes (KDIGO), CKD stage 4 (eGFR \< 30 ml/min, CKD stage 5 and end-stage renal disease on dialysis patients are excluded. * Patients with Acute Kidney Injury, stage 3. * Pregnant, or lactating * Known diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency * Patients who received the following medications within 7 days prior to enrollment, or plan to receive during enrollment, or 7 days after enrollment: aluminum hydroxide, b…