Quantifying the Epidemiological Impact of Targeted Indoor Residual Spraying on Aedes-borne Diseases (NCT04343521) | Clinical Trial Compass
CompletedNot Applicable
Quantifying the Epidemiological Impact of Targeted Indoor Residual Spraying on Aedes-borne Diseases
Mexico4,461 participantsStarted 2020-11-03
Plain-language summary
The objective of this trial is evaluate the efficacy of Targeted Indoor Residual Spraying (TIRS) in preventing symptomatic disease caused by Aedes-borne diseases (ABDs) in children 2 to 15 years of age in the city of Merida, Yucatan State, Mexico.
Who can participate
Age range
2 Years – 15 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Household Level Inclusion Criteria:
* Household is located within the bounds of a study cluster (5x5 city-block clusters)
* City block has at least 60% premises that are residential
Individual Level Inclusion Criteria:
* 2 or more and up to 15 years of age at the time of initial enrollment
* Living in a house that consented to TIRS (for children in TIRS cluster)
Exclusion Criteria:
Household Level Exclusion Criteria:
* Households where study personnel identify a security risk (i.e., site where drugs are sold, residents are always drunk or hostile)
* Sites where no residents spend time during the day (i.e. work 7days a week outside the home)
* Inability for a resident to provide informed consent
* Non-residential places (e.g., businesses, schools, markets, etc.)
Individual Level Exclusion Criteria:
* Less than 2 years of age or more than 15 years of age at the time of enrollment
* Not living in a house that consented to TIRS (for children in TIRS cluster)
* Having a medical condition that prevents implementation of study procedures
* Temporary visitor to household
* Plans to leave study area within next 12 months
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Number of Symptomatic Participants Testing Positive for Aedes-borne Virus Infections That Are Laboratory Confirmed or Serologically
Timeframe: 18 months of active surveillance during high transmission seasons (each 6 months in duration) during 3 years (July through December in 2021, 2022, and 2023)