Evaluation of the "Pupillary Pain Index" in Neurological Prognosis After Cardiac Arrest (NCT04336930) | Clinical Trial Compass
UnknownNot Applicable
Evaluation of the "Pupillary Pain Index" in Neurological Prognosis After Cardiac Arrest
60 participantsStarted 2021-11-01
Plain-language summary
Two-thirds of patients admitted to the Intensive Care Unit after a cardiac arrest die in the context of treatment withdrawal after a multimodal evaluation that determines an unfavorable neurological outcome.
This study will evaluate the Pupillary Pain Index (PPI) in the neurological prognosis after cardiac arrest. The PPI is determined by recording of pupillary dilatation with a videopupillometer after a calibrated and incremented nociceptive stimulus on a cutaneous metamere.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Admission to the ICU after cardiac arrest
* Age \> 18 years
* Presenting a Glasgow score of \<8 at admission
Exclusion Criteria:
* Pregnancy
* Ocular pathology making pupillometry impossible.
* Patient under guardianship or curatorship
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial is studying whether the 'Pupillary Pain Index' — a measurement of how pupils respond to pain stimulation — can help predict brain recovery after cardiac arrest, can you explain how that type of monitoring might affect decisions about my loved one's care?
2The trial is measuring outcomes using something called the Cerebral Performance Category (CPC) score, which rates brain function after cardiac arrest — can you walk me through what the different CPC levels mean and how that scale is used in my loved one's current situation?
3Because this study appears to be observational or diagnostic in nature rather than testing a new treatment, does participating mean anything about my loved one's actual treatment plan would change, or is it purely about collecting additional measurement data?
4The recruitment status for this trial is listed as unknown, which may mean it's no longer actively enrolling — is this study still open at your hospital, and if not, are there similar studies looking at neurological prognosis tools after cardiac arrest that we should know about?
5Given that predicting brain recovery after anoxic injury can be very uncertain, how does a tool like the Pupillary Pain Index fit alongside the other prognostic tests you're already using, and would discussing this trial help clarify the overall picture of my loved one's prognosis?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.