The regulation of clitoral vascularization by sex steroids is still under-investigated. We aimed to explore the effects of 6 months transdermal Testosterone (T) therapy on clitoral color Doppler ultrasound (CDU) parameters in pre- and postmenopausal women with female sexual dysfunction (FSD). In order to do that, we retrospectively recruited n=81 women with FSD, divided into 4 groups according to different treatments followed as per clinical practice, for 6 months: transdermal systemic 2% T gel; local estradiol ovules; local non-hormonal moisturizers; transdermal T plus local estrogens. Our main hypothesis is that systemic T treatment is able to positively modulate clitoral blood flow in basal conditions, specifically to increase clitoral artery Peak systolic velocity (PSV).
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Changes of clitoral artery peak systolic velocity (PSV) in women treated with testosterone gel
Timeframe: 6 months
Changes of clitoral artery pulsatility index (PI) in women treated with testosterone gel
Timeframe: 6 months
Changes of clitoral artery acceleration (ACC) in women treated with testosterone gel
Timeframe: 6 months