CompletedNot Applicable

RTSS Vaccine and PBO Net Impact on Malaria Infection and Transmission in Malawi

Malawi1,691 participantsStarted 2020-02-04

Plain-language summary

The overall goal of this study is to assess the impact of RTS,S (malaria) vaccination and PBO nets on malaria infection and transmission, independently and how they interact when they are introduced together. The specific objectives for the study are as follows: 1. To estimate the impact of PBO nets and RTS,S vaccine on Plasmodium infection prevalence and transmission, independently and how they interact when they are introduced together in Malawi (Phase 1). 2. To assess the feasibility of evaluating the impact of RTS,S vaccine and PBO nets independently in a larger scale future study.

Who can participate

Age range7 Months – 10 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Children aged 7 to 18 months of age (age-eligible for at least 3 doses of RTS,S doses) OR being one of not more than two children living in the household of an enrolled age-eligible child and being \>18 mos and \< 10 years of age. * Not on cotrimoxazole prophylaxis for HIV infection * Weight \>5 kg * Permanent residence of Health Centre (HC) catchment area * Residence within 10 km from the HC * Written informed consent from parent/guardian for the child to participate in the study Exclusion Criteria: Non-residents of the catchment area and visitors to the study area will be excluded because the study requires follow-up for at least 6 months and access to interventions such as conventional, PBO nets and malaria vaccination.

What they're measuring

Malaria infection prevalence

Timeframe: 6 months/cohort, 4 cohorts in Phase 1

Anopheles species abundance

Timeframe: 6 months/cohort, 4 cohorts in Phase 1

Trial details

NCT IDNCT04327440

SponsorMichigan State University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-06-30