CompletedNot Applicable

The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia

Russia60 participantsStarted 2020-01-01

Plain-language summary

Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization. The research team is considering that oropharyngeal decontamination with bacteriophages can prevent the developing of the ventilator - associated pneumoniae. There will be three groups in this investigation: placebo, antiseptic drug (Octenisept) and bacteriophage (Sexthaphag).

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: \- invasive mechanical ventilation beyond 48 hours Exclusion Criteria: * hospital - acquired pneumonia * community - acquired pneumoniae * BMI \> 35 kg/cm2 * pregnancy * tracheostomy * reintubation

What they're measuring

Incidence of ventilator-associated pneumonia (VAP)

Timeframe: Change from Baseline CPIS at 14 days

Changing of oral and lung microbiomes

Timeframe: Change from Baseline Microbiology researching at 14 days

Trial details

NCT IDNCT04325685

SponsorNorthern State Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-12-31

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