Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure

Inclusion Criteria: * between 18 and 65 years of age with painful defecation of at least 2 months duration and diagnosed with anal fissure between January and October 2019 were included. * The diagnosis of chronic anal fissure required : * the presence of internal sphincter muscle fibers in the base of the fissure * hypertrophic anal papillae on digital rectal examination Exclusion Criteria: * Patients with physical examination findings that did not meet the definition of chronic anal fissure * with painful defecation for less than 2 months, * atypical fissure location or multiple anal fissures away from the midline * inflammatory bowel disease * cancer * history of trauma * tuberculosis * immune suppression * sexually transmitted disease * a disease possibly associated with a fissure * a history of anal surgery * previous treatment for anal fissure * current pregnancy .