TerminatedNot Applicable

Assessment of Donor Derived Cell Free DNA and Utility in Lung Transplantation

Stopped: Due to COVID and staffing shortages we decided to end the study with 40 participants instead of 50.

United States40 participantsStarted 2020-06-29

Plain-language summary

The use of Allosure to identify and quantify circulating donor-derived cell-free DNA to quantitate allograft injury in the early post-transplant period and determine its relationship to allograft failure.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 years or above. * Denovo lung transplant recipient * Ability to understand written and spoken English Exclusion Criteria: * Previous transplant or multi-organ transplant * Unable to have blood draw for medical reason

What they're measuring

Number of Participants With Primary Graft Dysfunction/Allograft Rejection 24 Hours Post Transplant

Timeframe: 24 hours post transplant

Number of Participants With Primary Graft Dysfunction/Allograft Rejection 48 Hours Post Transplant

Timeframe: 48 hours post transplant

Number of Participants With Primary Graft Dysfunction/Allograft Rejection 72 Hours Post Transplant

Timeframe: 72 hours post transplant

Number of Participants With Allograft Rejection 3 Months Post Transplant

Timeframe: 3 months post transplant

Number of Participants With Allograft Rejection 6 Months Post Transplant

Timeframe: 6 months post transplant

Number of Participants With Allograft Rejection 9 Months Post Transplant

Timeframe: 9 months post transplant

Number of Participants With Allograft Rejection 12 Months Post Transplant

Timeframe: 12 months post transplant

Trial details

NCT IDNCT04318587

SponsorPablo Sanchez

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12-31

Results submitted2024-01-02

View on ClinicalTrials.gov More Lung Transplant Failure and Rejection trials