The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI (NCT04316676) | Clinical Trial Compass
CompletedNot Applicable
The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI
United States20 participantsStarted 2021-06-16
Plain-language summary
The overall goal of this project is to compare the absolute quantification of myocardial perfusion done by using CT myocardial perfusion imaging (CT-MPI) and the coronary flow measured by using CT Fractional Flow Reserve analysis (CT-FFR) to the gold standard represented by PET myocardial perfusion imaging (PET-MPI).
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Referred for a clinically indicated CT-MPI for CAD assessment
* Must provide written informed consent prior to any study-related procedures being performed
* Must be willing to comply with all clinical study procedures
Exclusion Criteria:
* Pregnant or nursing females. The possibility of pregnancy will be excluded by testing (serum or urine ßHCG) within 24 hours before study agent administration, or if the woman has previous surgical sterilization, or if the woman is post-menopausal, with minimum one (1) year history without menses.
* Currently taking or has taken within 48 hours the following excluded medications:
* ActoPlus Met (Pioglitazone + metformin)
* Avandamet (Rosiglitazone + metformin)
* Fortamet (metformin)
* Glucovance (Glyburide +metformin)
* Glucophage (metformin)
* Glucophage extended-release (XR) (metformin)
* Glumetza (metformin)
* Janumet (Sitagliptin + metformin)
* Metformin
* Metaglip (Glipizide + metformin)
* Riomet (metformin)
* Acute psychiatric disorder
* Unwilling to comply with the requirements of the protocol
* Previously entered this study
* Known hypersensitivity to iodinated contrast material, beta-blockers, or pharmaceutical stressors used in this study
* Suffers from claustrophobia
* Impaired renal function (GFR \< 45 ml/min)
* Acute hypotension (\<100 mm Hg systolic)
* 2nd or 3rd degree atrioventricular (AV) block
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Myocardial Blood Flow
Timeframe: Day of PET-MPI Scan, and Day of CT-MPI and CT-FFR Scans (up to 90 days)
2
Coronary Flow Per CT-FFR
Timeframe: Day of CT-MPI and CCTA scans
3
Sensitivity of Myocardial Perfusion Abnormalities Diagnosis
Timeframe: Day 1 (day of scans)
4
Specificity of Myocardial Perfusion Abnormalities Diagnosis
Timeframe: Day 1 (day of scans)
5
Area Under the Curve (AUC) for Detection of Myocardial Perfusion Abnormalities