CompletedNot Applicable

Acute Health Effects of Passive Vape Among COPD Patients

Denmark16 participantsStarted 2017-03-01

Plain-language summary

The use of e-cigarettes is often permitted in otherwise smoke-free areas causing passive vape exposure for present individuals. Little is known about the potential adverse health effects of passive vape, and people with respiratory diseases may be more susceptible. The aim of the present study was to investigate local and systemic effects of short-term passive exposure to vape from e-cigarettes among patients with mild or moderate chronic obstructive pulmonary disease COPD in a randomized controlled double-blinded cross-over study.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Never smoker or ex-smokers ≥ 6 months * Aged 18+ * A known diagnosis of COPD (FEV1/FVC \< lower limit of normal, app. 70%) * MRC ≥ 2 or CAT score ≥ 10 Exclusion Criteria: * Exposure to smoking more than 30 min./day * Treatment with inhaled or oral corticosteroids * Known hypersensitivity to constituents in e-cigarettes * Any other disease that could influence the study parameters * Conditions that prevent safe access to the climate chambers (such as claustrophobia) * Perennial rhinitis * Deformed nasal airways * Not being able to change from long-acting medication to short-acting medication

What they're measuring

Change in Particles in Exhaled Air (Surfactant Protein A & Albumin)

Timeframe: At baseline (0 hour), after exposure (4 hours), and the day after exposure (24 hours)

Trial details

NCT IDNCT04316234

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-11-30

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