CompletedNot Applicable

Expanded NIPT for Pregnancy Complications

United States70 participantsStarted 2020-02-12

Plain-language summary

This study evaluates the utility of expanded panel non-invasive prenatal testing (NIPT) in detecting confined placental mosaicism of rare autosomal trisomies among pregnancies with placentally-mediated complications, including fetal growth restriction and severe preeclampsia.

Who can participate

Age range18 Years – 60 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of early onset (\< 34 weeks) severe fetal growth restriction, defined as estimated fetal weight less than 10th percentile with abnormal umbilical artery Dopplers OR estimated fetal weight less than 5th percentile alone OR biometric size at least 14 days behind expected dates Exclusion Criteria: * Maternal age \< 18 years * Multifetal gestation * Chronic hypertension require use of pharmacotherapy * Tobacco or drug use * Major congenital malformations

What they're measuring

Composite adverse pregnancy outcome

Timeframe: Through study completion, an average of 2 years

Trial details

NCT IDNCT04311749

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-06-30

View on ClinicalTrials.gov More Fetal Growth Restriction trials