RecruitingNot Applicable

Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry

Germany200 participantsStarted 2019-09-15

Plain-language summary

We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * autonomic neuropathy * Postural orthostatic tachycardia syndrome * hypermobile or classical Ehlers Danlos syndromes * Chronic fatigue syndrome, mast cell activation syndrome and/or PostCOVID * healty controls * between 18-80 years * in patients: diagnosis and clinical testing in our outpatient clinic * German speaking Exclusion Criteria: * pregnancy * Pacemaker or Deep brain Stimulation * sensory or motor Polyneuropathy * neurodegenerative disease

What they're measuring

Blood pressure

Timeframe: baseline, 3 months and 18 months

Heart frequency

Timeframe: baseline, 3 months and 18 months

Skin biopsy

Timeframe: baseline

Composite autonomic severity Score

Timeframe: baseline, 3 months and 18 months

Trial details

NCT IDNCT04310644

SponsorRWTH Aachen University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-09-15

Contact for this trial

Andrea Maier, physician

+492418089600 ans-ambulanz@ukaachen.de

View on ClinicalTrials.gov More Autonomic Neuropathy trials