Stopped: Study investigators became aware of an internal error that overrode randomization of providers; therefore, the study randomization for this study was no longer present.
Hydroxychloroquine (HCQ) is a disease-modifying, anti-rheumatic drug that regulates immune system activity and is typically prescribed to treat rheumatoid arthritis and systemic lupus erythematosus, as well as other immune conditions. Although generally well tolerated, study data have demonstrated that long-term use of HCQ may lead to irreversible and potentially vision-threatening retinal toxicity. The American Academy of Ophthalmology (AAO) issued guidelines in 2011, and again in 2016 that recommended dosing of HCQ be based on an individual's body weight, and also outlined how and when to screen for retinal toxicity. While clinicians have been aware of the potential side effects of HCQ for decades, studies have shown that many patients continue to receive higher than recommended doses. The goal of this study is to conduct a pragmatic trial to assess the utility of a new e-prescribing (eRX) interface for prescriptions of hydroxychloroquine (HCQ). The investigators will measure the effectiveness of the system in reducing the number of individuals prescribed HCQ over current guidelines by randomizing clinicians to the new interface. Ideally, the eRX interface will result in a lower number of potential adverse events (i.e. retinal toxicity) associated with high-dose, long-term use of HCQ.
Age range
120 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Prevalence of dosage above guidelines: 6.5 mg/kg (2011)
Timeframe: Post intervention: 1 year
Prevalence of dosage above guidelines: 6.5 mg/kg (2011)
Timeframe: Post intervention: 2 years
Prevalence of dosage above guidelines: 6.5 mg/kg (2011)
Timeframe: Post intervention: 3 years
Prevalence of dosage above guidelines: 5.0 mg/kg (2016)
Timeframe: Post intervention: 1 year
Prevalence of dosage above guidelines: 5.0 mg/kg (2016)
Timeframe: Post intervention: 2 years
Prevalence of dosage above guidelines: 5.0 mg/kg (2016)
Timeframe: Post intervention: 3 years