The current investigation takes advantage of both a progressive and adaptive assist-as-needed massed practice and time-sensitive neuroplasticity through exoskeleton assisted walking in order to induce greater recovery-oriented CNS plasticity and consequent gains in more independent walking.
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Functional Independence Measure (FIM) (aim 1)
Timeframe: Change from Baseline FIM at 10 weeks
Within-brain functional connectivity (aim 2)
Timeframe: Change from Baseline Within-brain functional connectivity at 10 weeks
TMS recruitment curve slope (aim 3)
Timeframe: Change from Baseline TMS recruitment curve slope at 10 weeks
electroencephalogram (EEG) (aim 3)
Timeframe: Change from Baseline EEG at 10 weeks
electromyography (EMG) (aim 3)
Timeframe: Change from Baseline EMG at 10 weeks
10MWT (aims 1-3)
Timeframe: Change from Baseline 10MWT at 10 weeks
6MWT (aims 1-3)
Timeframe: Change from Baseline 6MWT at 10 weeks
TUG (aims 1-3)
Timeframe: Change from Baseline TUG at 10 weeks
structural connectivity (aim 2)
Timeframe: Change from Baseline structural connectivity at 10 weeks